Synthesize of Sodium Alginate Hydrogel from Iranian Brown Seaweed as a Candidate for Biomedical Applications

Document Type : Original Article

Authors

1 Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran

2 Center for Nanoscience & Nanotechnology, Institute for Convergence Science and Technology (ICST), Sharif University of Technology, Tehran, Iran

Abstract

 Hydrogels, which are cross-linked networks of hydrophilic polymers, are considered
promising candidates for various biomedical applications due to their unique physical and
chemical properties. This property is especially beneficial in applications such as drug delivery,
where ease of administration is crucial. Among these materials, alginate, a natural polysaccharide
derived from brown seaweed, can form hydrogels through ionic cross-linking under mild
conditions without the need for toxic reagents, making it a popular choice in biomedical fields.
A primary source of alginates is brown seaweed, scientifically classified under the group
Phaeophyceae. Alginates are polysaccharides that are abundantly found in the cell walls of
these brown seaweed species. In this research, brown algae were systematically harvested
from the Oman Sea in southern Iran. After collection, the alginate was meticulously extracted
and purified process to ensure its quality and suitability for medical applications. A hydrogel
primarily composed of purified sodium alginate was then developed. Various techniques were
utilized to evaluate the properties of the resulting hydrogel, including detailed assessments of
its physical and morphological characteristics through Fourier transform infrared spectroscopy,
X-ray diffraction, gel fraction analysis, and rheological studies. To determine the safety and
compatibility of the synthesized hydrogel for biomedical applications, a cytotoxicity test was
conducted. The results of these studies indicate that the synthesized hydrogel holds considerable
promise as a candidate for biomedical applications, particularly in targeted therapies, thereby
opening avenues for future research in biomedicine and pharmaceutical innovation. As the
field continues to evolve, the implications of this study underscore the importance of exploring
natural biopolymers for sustainable biomedical applications

Keywords

References

Abbasinia S, Monfared-Hajishirkiaee R, Ehtesabi H. (2024). Nanocomposite sponge based on sodium alginate, polyvinyl alcohol, carbon dots, and woolly hedge nettle antibacterial extract for wound healing. Industrial Crops and Product. 214: 118554. DOI: 10.1016/j.indcrop.2024.118554
Abkenar A. (2021). Investigation of seasonal changes on the antioxidant activity of brown algae Nizamuddinia zanardinii pre- and post-Monsoon in North coasts of the Oman Sea. Iranian Scientific Fisheries Journal. 30 (5): 99-110. DOI: 10.22092/ISFJ.2021.125494.
Ahmed EM. (2015). Hydrogel: preparation, characterization, and applications: A review. Journal of Advanced Research. 6 (2): 105-121. DOI: 10.1016/j.jare.2013.07.006.
Bojorges H, López-Rubio A, Martínez-Abad A, Fabra MJ. (2023). Overview of alginate extraction processes: Impact on alginate molecular structure and techno-functional properties. Trends in Food Science & Technology. 140:104-142. DOI: 10.1016/j.tifs.2023.104142.
Calumpong HP, Maypa, AP, Magbanua, M. (1999). Population and alginate yield and quality assessment of four Sargassum species in Negros Island, central Philippines. Hydrobiologia. 398: 211-215. DOI: 10.1023/A:1017015824822.
Karaki N, Sebaaly C, Chahine N, Faour T, Zinchenko A, Rachid S, Kanaan H. (2013). The antioxidant and anticoagulant activities of polysaccharides isolated from the brown algae Dictyopteris polypodioides growing on the Lebanese coast. Journal of Applied Pharmaceutical Science. 3 (2): 43-51. DOI: 10.7324/JAPS.2013.30208.
Khajouei RA, Keramat J, Hamdami N, Ursu AV, Delattre C, Laroche C, Gardarin C, Lecerf D, Desbrières J, Djelveh G, Michaud P. (2018). Extraction and characterization of an alginate from the Iranian brown seaweed Nizimuddinia zanardini. International Journal of Biological Macromolecules. 118: 1073-1081. DOI: 10.1016/j.ijbiomac.2018.06.154.
Lee KY and Mooney DJ. (2012). Alginate: properties and biomedical applications. Progress in Polymer Science. 37 (1): 106-126. DOI: 10.1016/j.progpolymsci.2011.06.003.
Liang D, Lu Z, Yang H, Gao J, Chen R. (2016). Novel asymmetric wettable AgNPs/chitosan wound dressing: in vitro and in vivo evaluation. ACS Applied Materials & Interfaces.8 (6): 3958-3968. DOI: 10.1021/acsami.5b11160.
Mahmood A, Patel D, Hickson B, DesRochers J, Hu X. (2022). Recent progress in biopolymer-based hydrogel materials for biomedical applications. International Journal of Molecular Sciences. 23 (3): 1415. DOI: 10.3390/ijms23031415.
Monfared-Hajishirkiaee R, Ehtesabi H, Najafinobar S, Masoumian Z. (2023). Multifunctional chitosan/carbon dots/sodium alginate/zinc oxide double-layer sponge hydrogel with high antibacterial, mechanical, and hemostatic properties. OpenNano. 12: 100-162. DOI: 10.1016/j.onano.2023.100162.
Pereira L, Sousa A, Coelho H, Amado AM, Ribeiro-Claro PJ. (2003). Use of FTIR, FT-Raman, and 13C-NMR spectroscopy for identification of some seaweed phycocolloids. Biomolecular Engineering. 20 (4-6): 223-228. DOI: 10.1016/S1389-0344(03)00058-3.
Raus RA, Nawawi WMFW, Nasaruddin RR. (2021). Alginate and alginate composites for biomedical applications. Asian Journal of Pharmaceutical Sciences. 16 (3): 280-306. DOI: 10.1016/j.ajps.2020.10.001.
Saji S, Hebden A, Goswami P, Du C. (2022). A brief review of the development of the alginate extraction process and its sustainability. Sustainability. 14 (9): 5181. DOI: 10.3390/su14095181.
Sundarrajan, P, Eswaran, P, Marimuthu A, Subhadra, L.B. and Kannaiyan, P. (2012). One pot synthesis and characterization of alginate stabilized semiconductor nanoparticles. Bulletin of the Korean Chemical Society. 33 (10): pp.3218-3224. DOI: 10.5012/bkcs.2012.33.10.3218.
Thu HE and Ng SF. (2013). Gelatine enhances drug dispersion in alginate bilayer film via the formation of crystalline microaggregates. International Journal of Pharmaceutics. 454 (1): pp.99-106. DOI: 10.1016/j.ijpharm.2013.06.082.
Wang H, Liu Y, Cai K, Zhang B, Tang S, Zhang W, Liu W. (2021). Antibacterial polysaccharide-based hydrogel dressing containing plant essential oil for burn wound healing. Burns Trauma. 22: 9: tkab041. DOI: 10.1093/burnst/tkab041.
Yazdani P, Zamani A, Karimi K, Taherzadeh MJ. (2015). Characterization of Nizimuddinia zanardini macroalgae biomass composition and its potential for biofuel production. Bioresource Technology. 176: 196-202. DOI: 10.1016/j.biortech.2014.10.141.
Ye S, Xie C, Agar OT, Barrow CJ, Dunshea FR, Suleria HA. (2024). Alginates from brown seaweeds as a promising natural source: A review of its properties and health benefits. Food Reviews International. 23: 1-29. DOI: 10.1080/87559129.2023.2279583.
Plant, Algae, and Environment
Volume 8, Issue 2
2024
Pages 1493-1504

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